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The following table is a guide for the initial daily dose of valproic acid (15 mg/kg/day): 2.2 General Dosing Advice Dosing in Elderly Patients Due to a decrease in unbound clearance of valproate and possibly a greater sensitivity to somnolence in the elderly, the starting dose should be reduced in these patients

While several double-blind RCTs demonstrate therapeutic potential particularly in reducing hyperactivity, irritability, and enhancing social functionings (Voigt et al., 2024), other trials fail to show benefits on core ASD symptoms (Mazzone et al., 2024)

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